MME Calculator

Calculate Morphine Milligram Equivalents (MME) for opioid medications using CDC guidelines with comprehensive safety assessment and risk analysis

Medical Disclaimer: This tool is for educational purposes only. Always consult clinical guidelines and use professional judgment for patient care.

Clinical Scenarios

Opioid Medications

Medication 1

Medication

Dose (mg)

Frequency/day

Route

Daily dose: 20 mg/day

CDC Guidelines

Risk Thresholds:

• <50 MME/day: Lower risk

• 50-89 MME/day: Moderate risk

• 90-199 MME/day: High risk

• ≥200 MME/day: Very high risk

Key Recommendations:

• Avoid exceeding 90 MME/day when possible

• Naloxone for patients ≥50 MME/day

• Regular risk-benefit assessment

• Consider non-opioid alternatives

Important Notes

Limitations:

• MME is an estimate, not absolute equivalence

• Individual patient factors vary greatly

• Cross-tolerance affects conversions

• Clinical judgment is essential

Special Considerations:

• Methadone has complex pharmacokinetics

• Fentanyl potency requires extra caution

• Route of administration affects conversion

• Age, renal function, and genetics matter